Caplyta weight gain. See full prescribing information for CAPLYTA.

Caplyta weight gain Lumateperone can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. Jul 20, 2022 · Reviews and ratings for Caplyta when used in the treatment of bipolar disorder. In general, antipsychotics as a class can be associated with weight gain as a common side Compare Caplyta vs Ziprasidone head-to-head with other drugs for uses, ratings, cost, side effects and interactions. Nov 17, 2025 · The FDA has approved Caplyta (lumateperone) as an adjunctive therapy with antidepressants for the treatment of MDD in adults. 4 days ago · Curious what is another name for lumateperone? It's known by the brand name Caplyta. Always consult your healthcare provider for This drug review provides a comprehensive analysis of a novel antipsychotic called lumateperone, marketed as Caplyta. Potentially clinically significant (PCS) weight increase (≥7% increase in weight from baseline) was reported in 66/779 patients (8. 06 kg CAPLYTA + ADT, 0. I would love to try caplyta again or especially a lower dose of vraylar + caplyta at the same time. Read firsthand experiences. Schizophrenia is a brain disorder with symptoms that include hearing voices In clinical trials, Caplyta demonstrated a relatively favorable safety profile compared to Invega. Lumateperone has properties that potentially make it more than just a “me-too” drug. Caplyta is an atypical antipsychotic that is used to treat schizophrenia and bipolar depression in adults. Caplyta is a new medication that helps treat depression and other conditions without weight gain. Mar 17, 2025 · See what Caplyta users say about weight gain. ⦁ New lower-dose capsules to be used for patients with moderate or severe hepatic impairment or those taking potent CYP3A4 inhibitors. These highlights do not include all the information needed to use CAPLYTA safely and effectively. Regular monitoring of these levels is essential. Clozap-ine has been associated with excess risk of myocarditis and venous thromboembolic events including fatal pulmonary embolism. CAPLYTA and other medicines may affect each other causing possible serious side effects. Even a small increase in appetite that you don't really notice can result in you eating enough to gain a good chunk of weight. Jul 24, 2025 · Caplyta package insert / prescribing information for healthcare professionals. CAPLYTA® (lumateperone) capsules, for oral use Initial U. 5%), while PCS weight decrease (≥7% decrease in weight from baseline) was reported in 75/779 patients (9. Jun 10, 2025 · Studies of Caplyta have reported weight gain but it’s not clear whether this is caused by the drug. 09 lbs or 0. The review Clozapine also causes granulocytopenia or agranulocytosis in approximately 1 percent of patients requiring regular blood cell count monitoring. Hence, the search for antipsychotics that either do not promote weight gain or, ideally, support weight loss has gained momentum. Out of 196 reviews, 13 (6. Caplyta is used in adults to treat: schizophrenia depressive episodes related to bipolar disorder The active ingredient in I take Saphris (asenapine) and it works really well for me and no weight gain. Uncontrolled body movements (tardive dyskinesia, TD) in your face, tongue, or other body parts. Based on animal studies, this medication might cause fertility problems in males and females. Caplyta is a D1 and D2 agonist (promoter)! It has been remarkable for keeping me level and helping with my depression without causing any weight gain whatsoever. Your doctor should check your blood sugar, fat levels, and weight before you start and during your treatment with CAPLYTA. I wonder why Caplyta causes weight loss instead of weight gain but I’m sure this will be beneficial for a lot of those who want an alternative to weight gaining antipsychotics. Movement disorders, including inner feelings of restlessness or the need to move around (akathisia) were not common when taking CAPLYTA. Aug 25, 2025 · Caplyta schizophrenia eases hallucinations and delusions, offering reliable relief while reducing weight gain and movement side effects. I just put on 12 lbs in six weeks on Abilify and am looking for alternatives. Find out how these drugs compare. Compare Caplyta vs Quetiapine head-to-head with other drugs for uses, ratings, cost, side effects and interactions. If you feel mentally stable with the medication regimen then it's worth continuing but if your weight reduces your stability it's important to let your doctor know. This is also known as metabolic syndrome. Antipsychotic-induced weight gain is a major management problem for clinicians. If you're concerned about weight gain your best bet is to watch your calories so you don't accidentally overeat. Includes: indications, dosage, adverse reactions and pharmacology. I was only on it for like a month at 42 mg and it didn’t work so I went back to 9 mg of Vraylar. DRUG TRIALS SNAPSHOT SUMMARY: What is the drug for? CAPLYTA is a drug used for the treatment of schizophrenia in adults. 1 out of 10 from a total of 550 ratings on Drugs. Your doctor will Nov 6, 2025 · Common side effects include dizziness, drowsiness, dry mouth, and nausea. Learn more about this breakthrough. It’s used to treat schizophrenia and bipolar depression (depressive episodes associated with bipolar 1 or 2 disorder). Caplyta's safety profile has been well-established in clinical trials, with a low risk of adverse events. Compare Caplyta vs Lurasidone head-to-head with other drugs for uses, ratings, cost, side effects and interactions. Nov 12, 2025 · Key Takeaways Lumateperone (Caplyta) is approved as an adjunctive therapy for MDD, showing significant improvement in depressive symptoms in clinical trials. 2%) Weight gain (6. Mild side effects include nausea, weight gain, and headache, and these may go away after a few weeks. Thanks for the reply. Nov 11, 2025 · A phase 3, 6-week, randomized, double-blind, placebo-controlled study evaluating CAPLYTA 28 mg and 42 mg as adjunctive therapy with lithium or valproate for bipolar depression reported mean body weight changes were minimal across all groups. Caplyta is my savior. Nov 17, 2025 · May also cause undesirable changes in blood cholesterol and lipid levels or weight loss or gain. On the other hand, Latuda, or lurasidone, is a second-generation antipsychotic that has also been studied for its safety and efficacy. Please continue reading to learn which medications are best tolerated and Jul 11, 2025 · Latuda (generic name: lurasidone) has a low risk for weight gain in adults and children with schizophrenia or bipolar depression, but this can vary in individual patients. Tell your doctor if any of these symptoms are severe or do not go away: extreme tiredness or fatigue weight gain nausea dry mouth dizziness Some side effects can be serious. 4) at Day 350. Gain an understanding of bipolar depression and its impact. It has been shown that weight gain and obesity lead to increased cardiovascular and cerebrovascular morbidity and mortality, reduced quality of life and poor drug Jul 12, 2024 · Learn about the side effects of Caplyta (lumateperone), from common to rare, for consumers and healthcare professionals. Your health care provider may ask you for a blood sample to check your cholesterol, blood sugar, and hemoglobin A1c (a measure of blood sugar over time) while you take this medication. Caplyta can cause side effects (also called adverse effects) that range from mild to serious. In contrast, Rexulti has been associated with a higher risk of weight gain and metabolic changes. Weight gain (6. Caplyta’s Unique Pharmacological Profile On average, patients did not experience weight gain (-0. Serious Side Effects of Caplyta In schizophrenia, lumateperone was associated with mild weight gain (mean difference ≤1 kg) compared to placebo, which was less than the weight gain observed with many other antipsychotics. Learn more about common, mild, and serious side effects of Caplyta. " 42mg, 6 months on drug No side effects (yet) No drowsiness No heat problems but I run really cold Haven’t had SI since I’ve started, but doesn’t keep mania at bay, it def tempers it though (like still spending, making different decisions than I normally would but not harmful decisions but out of character, etc), Caplyta is saving my life right now and I didn’t gain anymore weight like Data also showed that Caplyta did not increase mean weight gain, metabolic changes, or reported sexual side-effects. While all agents in the class have been shown to produce some changes, each drug has its own specific risk profile. Invega, on the other hand, has been linked to a higher risk of metabolic changes, such as weight gain and increased blood sugar levels. Both medications share common side effects like movement disorders, drowsiness, weight gain, and nausea. 6 But lamotrigine is the better tolerated option, with few of the adverse effects that matter most to patients: weight gain, fatigue, sexual dysfunction, and long-term medical risks. However, Caplyta does come with some important precautions and potential risks. Jun 13, 2025 · Caplyta, which is used to treat schizophrenia and depression related to bipolar disorder, can cause side effects. Try to CAPLYTA, like other drugs used to treat schizophrenia, may cause problems with your metabolism, including high blood sugar, diabetes, increased fat (cholesterol and triglyceride) levels in your blood, and weight gain. · Problems with your metabolism including high blood sugar, diabetes, increased fat (cholesterol and triglyceride) levels in your blood and weight gain. Jan 5, 2024 · Weight gain *All medications, including Caplyta, can cause side effects which can be mild or serious. The most common side effects of CAPLYTA with an antidepressant include sleepiness, dizziness, nausea, dry mouth, feeling tired, and diarrhea In 6-week clinical trials: Weight gain was not common In 6‑week trials of people taking CAPLYTA with an antidepressant, weight gain with CAPLYTA was similar to an antidepressant alone. Approval: 2019 CAPLYTA- lumateperone capsule Intra-Cellular Therapies, Inc ---------- Nov 16, 2025 · Yes, Lumateperone caplyta is FDA-approved to treat schizophrenia in adults. Compare Caplyta vs Latuda head-to-head with other drugs for uses, ratings, cost, side effects and interactions. Weight gain has been observed with atypical antipsychotic use. Your healthcare provider can tell you if it is safe to take CAPLYTA with your other medicines. However, some agents are known for the extent of specific side effects, such as weight gain or sedation. You may report side effects to FDA at 1-800-FDA-1088. Nov 1, 2025 · This medicine may increase your weight. 6) Leukopenia, Neutropenia, and Agranulocytosis : In patients with pre-existing low white Jul 10, 2025 · Caplyta and Vraylar are two prescription drugs used to treat schizophrenia and other mental health conditions. Weight is so intertwined with self-esteem which can have a significant impact on anxiety and depression. I’ve heard of Zyprexa causing weight gain which is why they just released Lybalvi which is supposedly to help counteract the weight gain. Caplyta does not usually cause weight gain as a side effect, unlike some other antipsychotics. ⦁ In studies to date, lumateperone appears to have low levels of akathisia, weight gain, metabolic side efects, and prolactin elevation. In clinical trials, Caplyta was found to have a lower incidence of weight gain, metabolic changes, and other safety concerns associated with antipsychotic use. 04 kg placebo + ADT) or metabolic impact at 6 weeks1,2† * Limitation: This open-label safety extension trial was designed primarily to assess long-term safety and tolerability. Mar 17, 2025 · After four years and as many different prescriptions, a 30+ lb weight gain, and blood glucose & cholesterol levels off the charts, my doctor prescribed the new drug, Caplyta. I also gained weight on caplyta- about 30- 40 pounds. Where should I keep my medication? Keep out of the reach of children and pets. You should talk with your doctor and pharmacist about any questions you have and to understand the potential side effects and benefits of any medication. Caplyta? Has anyone here tried this since it was recently approved for bipolar depression? I gain weight like it’s my job on every atypical, but I hear Caplyta is different. In fact, a head-to-head comparison of Caplyta vs Abilify found that patients taking Caplyta experienced fewer side effects, including a lower incidence of weight gain and metabolic changes. Mar 13, 2025 · Caplyta, which is used to treat schizophrenia and more, can cause side effects. Metabolic Changes, including hyperglycemia, diabetes mellitus, dyslipidemia, and weight gain. CAPLYTA® is a medication for bipolar I and II depression in adults. Nov 14, 2025 · The FDA has approved Caplyta (lumateperone) as an adjunctive therapy with antidepressants for the treatment of major depressive disorder in adults. In contrast, a minimal increase in weight was reported with cariprazine and asenapine [64]. Seroquel made me gain so much weight and absolutely impossible to lose it. Learn more about the evidence, side effects and alternatives of Caplyta for schizophrenia and bipolar depression. Nov 15, 2024 · Understanding the Importance of Weight Management is crucial for patients on antipsychotic medications, as gaining weight can negatively impact both physical and mental health. In general, Latuda caused minimal weight gain either in the short-term or the longer-term studies conducted by the manufacturer. ⦁ Lower afinity at D2 receptors means relatively lower risk for EPS. 5 days ago · Caplyta (Lumateperone Capsules) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. May 13, 2020 · Lurasidone is the more effective of the two, with a number needed to treat (NNT) of 5 compared to lamotrigine’s 12. Bipolar Depression If signs and symptoms of TD appear, consider discontinuing CAPLYTA if clinically appropriate. Aug 18, 2022 · Abstract Background: Antipsychotic-induced weight gain (AIWG) is a clinically relevant and concerning adverse effect of contemporary antipsychotic medications. 7%) View all Caplyta side effects Drug Class Antimanic agents Atypical antipsychotics Atypical antipsychotics Generic Availability Lower cost generic No lower cost generic approved No lower cost generic approved Pricing and Coupons * Prices are without insurance View all Lithium prices We could not find an exact match for Jan 2, 2021 · Abilify is more activitating, caused weight gain, and addiction issues. This is not a comprehensive list of all possible side effects. On the other hand, Rexulti is less likely to cause movement side effects but can lead to moderate weight gain. Problems with your metabolism including high blood sugar, diabetes, increased fat (cholesterol and triglyceride) levels in your blood and weight gain. Compare Caplyta vs Vraylar head-to-head with other drugs for uses, ratings, cost, side effects and interactions. Feb 22, 2018 · Have you experienced weight gain or loss on Vraylar (Cariprazine)? If you’ve used Vraylar (Cariprazine) for any reasonable duration, leave a comment below mentioning whether you gained weight, lost weight, or experienced zero noticeable weight change throughout treatment. 47% of reviewers reported a positive effect, while 32% reported a negative effect. 2 Likes Compare Caplyta head-to-head with other drugs for uses, ratings, cost, side effects and interactions. 4 days ago · Learn if 42 mg of Caplyta is a lot by understanding the standard adult dosage for schizophrenia and bipolar depression, including factors that can necessitate a dose adjustment. When it comes to the safety of Caplyta vs Abilify, it's essential to consider the potential risks associated with each medication. Caplyta may be less likely to cause weight gain than many If signs and symptoms of TD appear, consider discontinuing CAPLYTA if clinically appropriate. Lumateperone gained FDA approval in 2019 for treating schizophrenia and later, in 2021, for treating bipolar depression. Just like any medication, antipsychotics’ side effects may affect people differently. Caplyta short term trial caused weight loss and sleepiness. If signs and symptoms of TD appear, consider discontinuing CAPLYTA if clinically appropriate. However, monitoring of weight, blood glucose, and lipids is still recommended for all patients. Oct 9, 2024 · Key takeaways Caplyta (lumateperone) and Vraylar (cariprazine) are second-generation antipsychotics. Compare Rexulti vs Vraylar head-to-head with other drugs for uses, ratings, cost, side effects and interactions. -Headache -Nausea -Weight gain This list may not describe all possible side effects. Caplyta can affect your alertness or coordination. The effects of Caplyta on weight have been studied in clinical trials, and the results appear to be favorable Preparing for your visit Use these questions with your healthcare provider to help start the conversation about CAPLYTA. 6%) mention weight gain. Both medications are taken once daily, but the dosing and side effect profiles differ Oct 18, 2025 · Are caplyta and Vraylar the same thing? Find out now. Superior results without weight gain or sexual side effects. Caplyta is approved for schizophrenia and bipolar I and II disorders, while Vraylar is approved for schizophrenia and bipolar I disorder. Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Nov 7, 2025 · Caplyta (lumateperone) is an atypical antipsychotic that may reduce weight and BMI over time. Weight gain may occur. Caplyta had higher rates of sleepiness as a side effect than Latuda. You and your healthcare provider should monitor your weight. Understanding this fact plays a vital role in treatment success. It has a favorable weight and metabolic profile compared to placebo in short-term and long-term trials. Additionally, its ability to influence glutamate, an important neurotransmitter involved in cognitive function, may help improve cognitive symptoms often seen in schizophrenia. Caplyta (lumateperone) is generally considered weight neutral, meaning it typically does not cause significant weight gain for most patients. Nov 10, 2025 · Patients (N=809) were administered CAPLYTA 42 mg once daily in the evening for 26 weeks. Your healthcare provider should check your blood sugar, fat levels and weight before you start and during your treatment with CAPLYTA. 131 reviews submitted with a 7. In some cases, weight gain may be a symptom of metabolic changes. Wow 15lbs is a lot! Especially when I hear people gain 15lbs or more from antipsychotics. Advise patient to monitor weight periodically. It may also occur after you stop taking CAPLYTA. 49% of reviewers The objective is to conduct a systemic review of published clinical studies assessing the current state of the evidence on the association between lumaterpone and antipsychotic-induced weight gain (AIWG). Also, you could use metformin, Topamax, or other meds to prevent/treat antipsychotic-induced weight gain. Hyperglycemia, in some cases extreme and associated with ketoacidosis, hyperosmolar coma or death, has been reported in patients treated with antipsychotics. See the effects of CAPLYTA on metabolic and endocrine parameters, including body weight and prolactin, in adults with schizophrenia. It can also occur after CAPLYTA is discontinued. 9 out of 10 from a total of 1109 ratings on Drugs. Your healthcare provider should check your blood sugar, fat levels, and weight before you start and during your treatment with CAPLYTA. More about Olanzapine More about Vraylar (cariprazine) More about Caplyta (lumateperone) Ratings & Reviews Olanzapine has an average rating of 5. (5. Jul 11, 2024 · It’s worth noting that the incidence of weight gain and metabolic disturbances with Caplyta appears to be lower compared to many other antipsychotic medications, which is a significant advantage for long-term treatment. Lumateperone may cause side effects. In addition, quetiapine (Seroquel) is available as a generic, but Caplyta (lumateperone) is brand name only. Your doctor may need to check your weight on a regular basis while you are using this medicine. After four years and as many different prescriptions, a 30+ lb weight gain, and blood glucose & cholesterol levels off the charts, my doctor prescribed the new drug, Caplyta. For those of you that experience akathisia on common bipolar 2 meds, what are the best meds in your experience that don't cause much weight gain? Protect from falls. Examples include dizziness and dry mouth. Two months on it, and I’ve lost everything I gained and more from when I was on Abilify. Inform patient that lumateperone may cause weight gain. May 20, 2025 · Caplyta may cause some side effects. The only downside is that it's sublingual and you have to hold it there under your tongue for at least 10 minutes and it tastes like antiseptic and sadness. Lumateperone is a novel antipsychotic, which became commercially available in 2020 and received Food and Drug Administration approval for schizophrenia and bipolar disorder in 2019 and 2021, respectively. Most people experience noticeable symptom improvement after 4 to 6 weeks of treatment. Learn about symptoms, the difference between bipolar I and bipolar II depression, and hear from a real patient. Discover what symptoms does Caplyta treat and its benefits for mental health management. Medications that caused me little to no weight gain: Caplyta, Vraylar, Geodon, Latuda. It can also affect your body’s ability to regulate temperature. Caplyta is less likely to cause weight gain compared to many other antipsychotics, but Vraylar is known for leading to minimal weight gain. Caplyta demonstrates a favorable safety profile with minimal weight gain, metabolic changes, and extrapyramidal symptoms, addressing common adverse effects of other treatments. . Click to learn more about it. Please see Medication Guide, including Boxed WARNINGS. You may also be more Compare Caplyta vs Lybalvi head-to-head with other drugs for uses, ratings, cost, side effects and interactions. In clinical trials, CAPLYTA was associated with a relatively low incidence of clinically significant changes in weight, glucose, and lipid parameters compared to some other atypical antipsychotics. Vraylar has an average rating of 6. Nov 14, 2025 · Caplyta for depression received FDA approval in November 2025. Grapefruit and grapefruit juice may increase the blood levels of lumateperone. com. In conclusion, while both Caplyta and Rexulti have a good safety profile, Caplyta vs Rexulti: which one is safer? Compare Caplyta vs Risperdal head-to-head with other drugs for uses, ratings, cost, side effects and interactions. Learn about this atypical antipsychotic, its uses, and how it works for schizophrenia and bipolar depression. Reply reply simbimba • Weight gain from meds boils down to 1 thing 99% of the time - they cause an increase in appetite, you eat more, and you gain weight. I'm not on a diet but still losing the Seroquel weight. Call your doctor for medical advice about side effects. Caplyta was ranked second for best-tolerated medication, and Latuda was ranked third. May cause seizures and drowsiness. Explore its history, key milestones, and timeline for treating mental health conditions. 5. Compare Caplyta vs Invega head-to-head with other drugs for uses, ratings, cost, side effects and interactions. Good luck, I LOVE Caplyta. See full prescribing information for CAPLYTA. Results from a number of trials combined together showed that the weight gain observed in patients treated with Caplyta was similar to the weight gain observed in patients who Although all the newer antipsychotics had significantly favorable metabolic characteristics compared to olanzapine, the risk of weight gain and increased body mass index was more with brexpiprazole and iloperidone among the newer antipsychotics. I am down around 30 lbs since March. Tiredness (9. Jan 20, 2025 · Benefits: Caplyta is associated with a lower risk of common side effects like weight gain and sedation, which are often seen with other antipsychotics. Caution patient to avoid driving or other activities requiring alertness until response to drug is known. Talk to your doctor about ways to prevent weight gain. However, Caplyta was associated with lower rates of weight gain than placebo and the other antipsychotics. Notify health care professional of significant weight gain. CAPLYTA, like other drugs used to treat schizophrenia, may cause problems with your metabolism, including high blood sugar, diabetes, increased fat (cholesterol and triglyceride) levels in your blood, and weight gain. Nov 16, 2025 · Caplyta is FDA-approved to treat symptoms of schizophrenia and bipolar depression. This drug may also cause significant weight gain and a rise in your blood cholesterol (or triglyceride) levels. Extrapyramidal Symptoms (EPS): These are drug-induced movement disorders, including tremors, rigidity, and restlessness. Long-term data indicates Caplyta's safety and efficacy, with I gained a ton of weight on Seroquel but once switching to other medications I rarely have any weight gain. In some cases, this may increase the risk of side effects such as drowsiness, abnormal muscle movements, seizures, high blood sugar, diabetes, high cholesterol, weight gain, low white blood cell count, difficulty swallowing, and heat-related disorders such as heat intolerance or heat stroke. Learn how this atypical antipsychotic works, its efficacy, and side effects. 6) at Day 175 and approximately - 3. While both are atypical antipsychotics, they are not identical. Aug 7, 2024 · Latuda ranked second, and Caplyta ranked third in terms of efficacy. In an uncontrolled open-label trial of CAPLYTA for up to 1 year in patients with stable schizophrenia, the mean change in body weight was approximately -2 kg (SD 5. When treating pediatric patients with atypical antipsychotic agents, weight gain should be monitored and assessed against that expected for normal growth. If you experience any of these symptoms or those listed in the IMPORTANT WARNING or the SPECIAL PRECAUTIONS sections, call your doctor immediately or get emergency medical treatment Compare Caplyta vs Rexulti head-to-head with other drugs for uses, ratings, cost, side effects and interactions. " Vraylar is less likely to cause weight gain compared to other antipsychotics, but it has a higher risk of causing uncontrolled muscle movements. To date, no comprehensive Jan 17, 2025 · Does Caplyta Cause Weight Gain? One of the most common questions that people have about Caplyta is whether or not it causes weight gain, which is a sensible question given that many antidepressants are associated with weight gain, as we documented in our Paxil reviews article. Yes! I was on Seroquel and switched to Caplyta. It is important to inform your doctor if any of these side effects persist or worsen. Feb 23, 2020 · Caplyta is a D1 and D2 agonist (promoter)! It has been remarkable for keeping me level and helping with my depression without causing any weight gain whatsoever. 6%). Mar 1, 2023 · Lumateperone (Caplyta, Intra-Cellular Therapies) is a new antipsychotic medication, approved by the Food and Drug Administration (FDA) in 2019 for adults with schizophrenia and approved in 2021 for adults with depressive episodes associated with bipolar I or II disorder. Nov 7, 2025 · Continue reading Although Abilify (aripiprazole) has been found to cause less weight gain than other atypical antipsychotics, there is evidence that in certain people it can cause significant weight gain and it may be more likely to cause weight gain in people who are taking it for depression alongside other antidepressants. 7%) View all Caplyta side effects Drug Class Atypical antipsychotics Atypical antipsychotics Atypical antipsychotics Generic Availability Lower cost generic approved No lower cost generic approved No lower cost generic approved Pricing and Coupons * Prices are without insurance We could not find an exact match Compare Caplyta vs Invega head-to-head with other drugs for uses, ratings, cost, side effects and interactions. Learn how their active ingredients, approved uses, and side effect profiles differ for treating conditions like schizophrenia and bipolar depression. What about weight change? In a long-term study, patients on CAPLYTA for one year had an average weight loss of 7 pounds. Additionally, lumateperone showed favorable tolerability, with lower rates of discontinuation due to adverse events compared to risperidone. Lumateperone (Caplyta) treats depression (both bipolar and non-bipolar types), insomnia, anxiety, agitation, paranoia, and hallucinations. It belongs to a class of medications called the atypical antipsychotics, which differ widely in their side effects and benefits. As others have said, the mood stabilizer lamotrigine is relatively low risk with evidence for bipolar depression and maintenance. Learn about these side effects and more. In fact, some people have lost weight during treatment with Caplyta. 13 lbs or -0. Nov 13, 2025 · Caplyta (lumateperone) is less likely to cause certain side effects, such as movement-related side effects and weight gain, than quetiapine (Seroquel). Has anyone made the switch and have insights to share? Mostly eager to know: Was there an initial low before stabilizing when making the switch? How long before you started to feel better on Caplyta? Any temporary reactionary side effects like acne breakouts? When I first started Seroquel I had really bad Jul 11, 2023 · The most common side effects include drowsiness, dizziness, dry mouth, constipation, weight gain, and blurred vision. Sep 22, 2023 · Antipsychotic medications are used to treat mental illnesses. Extremely high blood sugar levels can lead to coma or death. Changes in laboratory blood cell tests such as leukopenia (low white blood cells), neutropenia (low neutrophils), and agranulocytosis (severe neutropenia) have been reported with antipsychotic agents including Caplyta. Sep 28, 2025 · Weight Gain. Caplyta may begin working within 1 to 2 weeks of starting it. Second generation antipsychotics (SGAs) increase the risk of weight gain, high blood sugar, and high cholesterol. 4 days ago · Find out exactly how long has Caplyta been around since its first FDA approval. Jul 31, 2024 · Dry Mouth Dizziness Nausea Weight Gain Constipation Serious Side Effects Metabolic Changes: Caplyta can cause increases in blood sugar, cholesterol, and triglycerides. Both medications can cause serious side effects like neuroleptic malignant syndrome and tardive dyskinesia. 5) Metabolic Changes: Monitor for hyperglycemia/diabetes mellitus, dyslipidemia, and weight gain. The most common side effects associated with Caplyta include dizziness, dry mouth, and weight gain. Please try it, and give it a few weeks. CAPLYTA may affect the way other medicines work, and other medicines may affect how CAPLYTA works. Jul 29, 2024 · Caplyta (lumateperone) is an atypical antipsychotic medication. Please see full Prescribing Information, including Boxed WARNINGS. My only problem is it gave me allergies. Switching over to Caplyta due to weight gain issues on Seroquel (150mg) for BP2. If signs and symptoms of TD occur consider discontinuing CAPLYTA treatment. Nov 6, 2025 · Caplyta (lumateperone) treatment is not associated with the weight gain that some other antipsychotic drugs are. If for bipolar depression specifically, Vraylar or Caplyta are other useful options with relatively low risk. Nov 5, 2024 · TD may not go away, even if CAPLYTA is discontinued. S. It’s my miracle all-in-one. TD may not go away, even if you stop taking CAPLYTA. These effects, along with diabetes, may increase your risk for developing heart disease. 0 average score (Page 2). Compare Abilify vs Caplyta head-to-head with other drugs for uses, ratings, cost, side effects and interactions. May 23, 2024 · While not common with Caplyta, antipsychotics may lead to weight gain, high blood pressure, diabetes, or high cholesterol. 2 kg (SD 7. Could adding CAPLYTA help improve my depression symptoms? How quickly will CAPLYTA start working? What are the common side effects of CAPLYTA? Will CAPLYTA make me gain weight? Can I take other medications with CAPLYTA? Is there a good time of day to take CAPLYTA? Will Can CAPLYTA help with my bipolar depression symptoms? How quickly will CAPLYTA start working? What are the side effects of CAPLYTA, and are they different from other bipolar depression medications? Do I need to take CAPLYTA with food? Will CAPLYTA make me gain weight? Can I take other medications with CAPLYTA? Do you think CAPLYTA would be Common side effects of Caplyta may include sleepiness, dizziness, nausea, and dry mouth. We found evidence of weight gain with brexpiprazole, risperidone and paliperidone, quetiapine, iloperidone, sertindole, olanzapine, zotepine, and clozapine (figure 2; appendix p 41). This is based Caplyta (lumateperone) treatment is not associated with the weight gain that some other antipsychotic drugs are. Apr 15, 2023 · Caplyta (lumateperone) is a prescription drug that’s used to treat schizophrenia and depressive episodes related to bipolar disorder. ifg pmzt fcb watf zxetb bewv uyk sobws jqrb vpjcbjkx iqqc kvtzeir zsp ujig hobp